HATU: High-Efficiency Peptide Coupling Reagent for Amide ...

2026-01-19

HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a premier peptide coupling reagent that delivers rapid, high-yield amide and ester bond formation. Its mechanism of activating carboxylic acids to OAt-active esters makes it indispensable in modern peptide synthesis chemistry.